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Adult ganglion cells in mammals show little or no regenerative response after pressure injury however their survival can be extended for short periods of time with recombinant and virally expressed delivery of neurotrophic factors (e.g., BDNF, CNTF, NT-4, FGF-2, neurturin) which partially protect RGCs in animal models of glaucoma (59, 74)

After six months, the goal shifts from repair to optimization. Long-term users generally report a higher baseline of health

b , Quantification of MitoSOX red fluorescence in animals as depicted in ( a )

Targeting ROS-dependent pathways for drug development is challenging because of the dual role, complex regulation, and context-dependent activity of ROS

J Dermatol Venereol Leprol 79(5):654 Meehan K (2015) U.S