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Upon perfusion, OPTEC tubules displayed proper polarization and expressed a broad array of proximal-tubule-specific functional markers, exhibiting higher expression levels of basolateral drug transporters, namely organic cationic/carnitine transporter 2 (OCT2), organic anion transporter 1 (OAT1) and OAT3, compared to immortalized PTECs

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In addition, several p53 mutations induce the expression of oncogenic proteins, resulting in a dominant-negative (DN) effect on wild-type p53

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