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Cell Culture HeLa cells were obtained from the Lerner Research Institute of the Cleveland Clinic Foundation (Cleveland, OH)

As a tumor suppressor, YY2 negatively regulates de novo serine synthesis by binding to the PHGDH promoter and repressing its transcriptional activity, thereby inhibiting tumorigenesis (104)

Prolonged use of glucocorticoids can lead to more serious complications, such as osteoporosis and adrenal suppression, necessitating careful management and potential adjunct therapies to mitigate these risks

Safety, efficacy, and pharmacodynamics of the investigational agent orteronel (TAK-700) in metastatic castration-resistant prostate cancer (mCRPC): updated data from a phase I/II study [abstract 98]

A study published in the Archives of General Psychiatry documented similar findings one year later in a 4-week-long Xanax withdrawal trial