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These findings have led to expanded indications for cardiovascular risk reduction even in patients without diabetes

Enhance athletic performance

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key activator of the antioxidant responsive element (ARE) (60, 61)

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O'Brien SM, Jabbour E, Thomas DA, Ravandi F, Cortes JE, Pemmaraju N, Kadia TM, Garris R, Jeanis V, Garcia-Manero G, Borthakur G , Wierda WG, Kantarjian HM