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doi:10.1080/09637486.2020.1852537 52

10.1007/s12035-014-8851-1 Mol Neurobiol

doi: 10.12691/jfnr-3-9-6 6 StefaniMRigacciS

Kupffer cells also express a complement receptor of the immunoglobulin family, without which the liver cannot clear complement systemcoated pathogens

Although the need for dose reduction in the healthy population seems largely unnecessary, it may be warranted in certain severe or decompensated hepatic disease states, particularly if patients are malnourished, are not eating or have a dry weight less than 50 kg