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Acknowledgements Special thanks are due to Paola Murano from Nefrocenter Research Network, for her complimentary editorial assistance, and to Members of the AMD-OSDI Study Group on Injection Technique for critical reading and approval of the manuscript

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To assess the suitability of syringetin for topical use, they administered 3 g/mL and 6 g/mL concentrations of syringetin in 31 volunteers via skin patches, demonstrating that syringetin is safe [72]