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Generally, apoptosis can be executed via two core pathways: extrinsic and intrinsic [75, 76]

Further studies are required to provide more evidence about the differences between RBC senescence and eryptosis

Histopathological evaluation using H&E staining (Figure 11A) revealed that neurons in the Ischemia-Reperfusion group were disorganized, exhibited contracted and irregular cell bodies, and displayed pyknotic nuclei with indistinct structural features

In this sense, scientific community is searching for new alternative noninvasive techniques or biomarkers for asthma phenotypes identification, treatment monitoring, exacerbations prediction, differential diagnosis of other pathologies with similar symptoms and personalized diagnosis when patients suffer from comorbidities such as rhinosinusitis or other atopic disorders 6,22,23

When cells are exposed to oxidative stress, the conformation of Keap1 changes, allowing Nrf2 to stabilize and translocate into the nucleus, where it activates the expression of a series of antioxidant genes 28