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10.1016/j.dsx.2018.08.035 17

PRZECIWWSKAZANIA Nie zaleca si stosowania u osb poniej 16-go roku ycia, kobiet w czasie ciy i w okresie karmienia piersi oraz w przypadku stwierdzonej nadwraliwoci na ktrykolwiek ze skadnikw preparatu

Because dialysis patient plasma free levocarnitine level can be starkly lower than normal person's level, the patient of dialysis more than 2 years all the levocarnitine deficiency disease can occur.Levocarnitine lacks can influence the oxidation of mitochondrion to free fatty, causes energy metabolism impairment, simultaneously, and owing to S-acetyl-coenzyme-A gathers at mitochondrion, but the effect of pair cell toxigenicity.Its clinical manifestation is hypotension, muscular spasm, cardiomyopathy, arrhythmia and the reduction of dialysis toleration etc., has a strong impact on patient's quality of life and secular survival rate, so it is very important to replenish levocarnitine

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Berberines anti-atherosclerotic efficacy potentially stems from its ability to reduce TMAO production, making it an excellent modulator for inhibiting atherosclerotic plaque development (Chen and Wang, 2021)