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Methodological caveat: Most human trials use combination formulations published studies often combine GHK-Cu with other actives (e.g., retinoids, vitamin C), making it difficult to isolate GHK-Cus independent contribution

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10.1124/dmd.110.037077 Drug Metab

AGEs can cause insulin resistance (IR), which may lead to T2DM and other metabolic syndrome conditions, such as high blood pressure and abnormal cholesterol or triglyceride levels [311]

However, when symptoms arise, both conservative and surgical treatments options can be considered when discussing what to do next