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LRP1 and LRP2, integral members of the LDL receptor family, are highly expressed in the BBB, making them attractive targets for drug delivery systems designed to facilitate brain penetration

However, effects of BPC 157 on vascular tone and intracellular Src-Cav-1-eNOS signaling are still not understood

Allosteric modulators Allosteric modulators typically attach to regions distinct from the orthosteric site of receptors, inducing conformational changes to regulate the affinity and/or efficacy of orthosteric ligands, or to directly modulate receptor activity with positive, negative, or neutral effects

Newton, 2007

In hypercholesterolemic mice, deletion of Arg2 or inhibition of arginase with BEC improves endothelial function and reduces atherosclerosis (Ryoo et al., 2008)