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However, uncontrollable release in other macrophage phenotypes or cells causes dose-dependent toxicity, which attributes to nonspecifically chelate physiologically essential iron

The decrease in the level of expression of genes responsible for the synthesis of superoxide dismutase increases with the increase in glutamine concentration

[2]Collins, C. B., Riskowski, R. A., Ackerson, C.J. Radiofrequency remote control of thermolysin activity. Sci Rep 2021 Mar 16;11(1):6070. doi: 10.1038/s41598-021-85611-w

156 Besides, with the consumption of extracellular glutamine, GDH can also catalyze ammonia derived from glutaminolysis and -KG to support the synthesis of glutamate and downstream metabolites by reductive amination in a NADPH consumption manner to meet the cancer cells growth

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