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Melatonin could resolve hyper-inflammatory conditions in COVID-19 and PASC by down-regulating proinflammatory cytokines (i.e., TNF-, IL-1, IL-6, and IL-8) and increasing anti-inflammatory cytokines such as IL-10 660,661

Avoid inhalation, ingestion, and contact with skin or eyes

For instance, based on solvent displacement, PLGA nanoparticles effectively entrap the poorly water-soluble Riluzole (RLZ, a neuroprotective drug)

doi: 10.1038/nm.4050 307 VeenGGiltayEJDeRijkRHvan VlietIMvan PeltJZitmanFG