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222, e202102119 10.1083/jcb.202102119 [DOI] [PMC free article] [PubMed] [Google Scholar] 105.Dissanayake, W.C., Sorrenson, B., Cognard, E., Hughes, W.E

As many as 73 percent of subjects experienced nausea, 47 percent vomiting, and 25 percent diarrhea

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Niacinamide (or nicotinamide) is a biologically active form of niacin (vitamin B 3 ) that has also been shown to inhibit melanosome transfer in a co-culture model of melanocytes and keratinocytes without impairing melanogenesis [137, 138]

It also enhances the body's antioxidation defense by boosting the activity of antioxidant enzymes SOD, GSH-Px, and CAT, reducing levels of lipid peroxidation products MDA and 4-HNE to protect hepatocytes and alleviate inflammation [143]