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Studies have shown that BET can significantly improve testicular histoarchitecture and sperm quality in a CRS mouse model, restoring the structural integrity of seminiferous tubules, likely by reducing testicular oxidative stress and levels of pro-inflammatory cytokines (including TNF- and IL-6) ( 4.6 Antifibrotic effect Testicular fibrosis is a hallmark feature of chronic testicular injury and a major contributor to irreversible spermatogenic failure

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Evans, R.M., Swanson, L., Rosenfeld, M.G

Transgenerational Effects of Prenatal Exposure to the Dutch Famine on Neonatal Adiposity and Health in Later Life

In homozygous LDLR mutant mice, it was shown in vivo that AAV-CRISPR/Cas9-mediated gene editing to correct the LDLR mutation resulted in decreased atherosclerosis and macrophage infiltration compared with placebo, as well as significant reductions in serum total cholesterol, LDL-C, and TG