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Together, these findings suggest that VRK2-deficient PC cells exhibit a metabolic preference for GSH dependency, implying that VRK2 has the potential to regulate GSH biosynthesis

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Evening administration is preferred to align with natural melatonin production cycles

Oral cyanocobalamin supplementation may be appropriate in dietary deficiency where absorption is intact

National Natural Science Foundation of China (32300068 to T.J., 91951204 to L.Y., 32270196 to L.Y., 32200155 to L.Y., 32200053 to L.Y., 32300060 to L.Y., and 32400154 to X.D.)