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Protein kinase C phosphorylates Ser40 of Nrf2, resulting in the activation of Nrf2 ( Figure 4B ) inhibits its activity by promoting -TrCP-mediated ubiquitination and degradation of Nrf2 (Rada et al., 2012)

In addition, it shows antithrombotic and antiviral effects, especially against vaccinia, herpes simplex, rhinovirus, human parainfluenza virus and vesicular stomatitis virus

Furthermore, nutritional overload can affect the normal function of the maternal immune system, inducing obesity-related inflammation and immune response, thereby exacerbating fetal oxidative stress and lipotoxicity [19]