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Yet, we noted that FUS-induced BBB opening combined with GSK-3 inhibitor delivery had an additive effect on plaques reduction efficiency reaching 39.6% reduction, compared to 15.1% with FUS-BBB opening alone and 22.6% with GSK-3 inhibitor administration alone (see Fig

The difference between recurrent and primary scores was defined as an indicator of drug sensitivity: positive values signified drug resistance, while negative values reflected drug sensitivity

Surprisingly, L-DKO mice did not die or significantly lose weight shortly after genetic deletion was induced (Fig

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(ii) the -ketoglutarate dehydrogenase complex that catalyzes the conversion of -ketoglutarate to succinyl CoA, another important intermediate of the citric acid cycle