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Additionally, an open-label, single arm pilot trial (OPTIMA) was designed to assess the efficacy and safety of inhaled GM-CSF (Molgramostim nebulized solution) in treating NTM-PD in adults with non-CF bronchiectasis ( Although these data have not fully demonstrated the exact efficacy of NE inhibitors in the treatment of bronchiectasis, researchers continue to explore and optimize the therapeutic strategies for NE inhibitors, including the development of inhaled NE inhibitors to increase the concentration of the drug in the lungs and thus improve the clinical efficacy

PMA stimulates expression of the NADPH oxidase components, gp91, p22, and p47, to facilitate NET release, which can be blocked by the glutamine metabolism inhibitor, 6-Diazo-5-oxo-l-norleucine ( Figure 3 )