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PMID: 32697831 OncoTargets and Therapy Dovepress 2020 May 18;15:1093-1101

Silverstein MicroWick

Reelin (RELN), a glycoprotein primarily secreted by a subset of GABAergic interneurons, is essential cortical neural connectivity during prenatal development and for synaptic plasticity postnatally, both of which are crucial for cognitive function and disrupted in schizophrenia (Negrn-Oyarzo et al., 2016)

D.JewellH.MaggsJ

Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)