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CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Jacobson, P

doi: 10.3390/ph12020093 94 MatsushitaM.FreigangS.SchneiderC.ConradM.BornkammG

The MTOB-transporter was identified as BAT5 or BASS5 following its activation in trans by R2R3 MYB factors regulating GSL biosynthesis ( BAT5 transcripts in bat5 mutant resulted in up to 50% decreased levels of Met-derived GSLs, indicating a role of BAT5 in the transport of GS intermediates across the plastid envelope ( bat5, its metabolic complementation by 2-keto-acids and genetic complementation using chemically inducible promoter fused to BAT5 CDS, the BAT5 has been proposed as a facilitator of keto-acids across chloroplasts ( bat5 roots of Arabidopsis with 2-keto acids with different chain-length demonstrated that they are substrates of BAT5 since they could be successfully imported into chloroplasts of wild-type plants but not in the bat5 plants

Some studies observed no significant changes in melanin indices, highlighting outcome variability, with individual differences, dosage, and treatment duration likely contributing to this inconsistency