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PMID: 17909804

Subramanian M, Hayes CD, Thome JJ, Thorp E, Matsushima GK, Herz J, et al

The DNA damage in the lymphocytes of people with obesity was found to be about twice as high as in the lymphocytes of normal-weight subjects

Paller and Mancini: Hurwitz Clinical Pediatric Dermatology

These all have side effects, but the biggest challenge with them is that they are daily oral medications, which can be forgotten, missed, or hard to adhere to