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Lvesque, M., Feng, Y., Jones, R

While it is widely used and generally safe to take at low dosage (the FDA-approved dose is less than 4 g per person per day), APAP is also the worlds leading cause of drug overdose and acute liver failure, with a number of these episodes being attributed to unintentional overdosing on APAP/opioid combination analgesics (Bunchorntavakul and Reddy 2013