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10.1016/s0002-9440(10)64787-6 Am

1.2.3 P62-Keap1-Nrf2 signal transduction pathway Other molecular signal pathways related to ferroptosis, including p62-Keap1-Nrf2 signal transduction pathway, bind to Kelch-like ECH-related protein 1(Keap1) under oxidative stress, and remain inactive through ubiquitination in proteasome, and then release Nrf2 from the coupled Keap1 protein and transfer to the nucleus (45)

Our role as clinicians is to understand the root cause before recommending any course of action

Rotenone induces aggregation of gamma-tubulin protein and subsequent disorganization of the centrosome: relevance to formation of inclusion bodies and neurodegeneration