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After the clinical observation of phenotypes attributable to PFIC, current research techniques enable the isolation of novel variants related to known genes or variants in other genes that determine known or new cholestatic intrahepatic phenotypes

Vitamin injections are intramuscular (IM) shots that deliver vitamins and nutrients directly into the muscle for faster absorption than oral supplements

Ethics approval and consent to participate All relevant ethics documents were approved by the Institutional Research Ethics Committee of Nanjing Medical University (for clinical patients) and Nanjing University (for mice)

Treatments that activated Wnt signaling from downstream, like lithium chloride or other GSK3-beta inhibitors, showed limited effectiveness for hair growth