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As a cofactor, cobalamins are essential for two cellular reactions: the mitochondrial methylmalonyl-CoA mutase conversion of methylmalonic acid (MMA) to succinate, which links lipid and carbohydrate metabolism, and the activation of methionine synthase, which is the rate-limiting step in the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate

Alternate between multiple sites to prevent lipohypertrophy (fatty lumps under skin), reduce scar tissue formation, and maintain consistent absorption

Serum B12 test: This is typically the initial test of B12

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