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GSH levels decrease with age and due to certain disease states e.g Type 2 Diabetes Mellitus, cardiovascular disease.(2) Oral NAC increases GSH levels by providing the liver with an increased supply of cysteine promoting an increase in GSH synthesis, and therefore reduce oxidative stress

(2) This indefinite decrease is known as somatopause and is associated with difficulty losing weight, bone mineral density loss, other age-related changes, and multiple health risks

Upon activation by ligand binding, AhR is released from the translocation inhibitory complex (formed by chaperone proteins HSP90 and XAP2) which reveals AhRs nuclear localization signal (NLS)

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