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However, this adaptation creates a dependency on continuous nutrient and energy supplies, beyond the well-documented glucose metabolism alterations, leading to enhanced production of amino acids and fatty acids to support tumor growth [79, 80]

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Prior to phylogenetic tree construction, several sequences were filtered out where isoforms were presented (180), short sequences (19) and alternative splice variants or fragmented sequences (15)

In the current study, 141 duplicate gene pairs were identified, including 10 containing pseudogenes