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doi: 10.1007/s12602-025-10559-6 124 BonfantiA

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 19 (COVID-19) has numerous risk factors leading to severe disease with high mortality rate

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With successive rounds of DNA replication in mitotic and highly metabolic cells, one could expect that the heart is largely affected, consistent with patient death

The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)