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Major challenges in current therapeutic strategies include: Pharmacological options, including antidepressants (duloxetine, milnacipran) and anticonvulsants (pregabalin), primarily target symptom relief without addressing the underlying pathophysiology

This multifunctional, negatively charged, and non-glycosylated protein also participates in the regulation of plasma osmotic pressure

Unlike many sensitive signaling peptides, BPC-157 shows remarkable resistance to degradation in human gastric juice ex vivo and standard saline solutions, maintaining structural stability for extended laboratory testing windows

5B) further confirms the moderate correlation (median = 0.14) between gene expression and protein levels, suggesting some divergence between mRNA and protein regulation

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