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(C) Acquired resistance mechanisms: Acquired resistance is mediated by secondary mutations in the target protein, activation of alternative pathways through other receptors or downstream proteins, or phenotypic transformation

At the same time, there was no evidence of ERK1/2 phosphorylation in KD cells, which might have contributed to the lingering unimpeded TGF-1 signaling

T.RajabniaM.et al

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Van Elswyk, M