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According to this proposal, the intestinal microbiota affects mechanisms related to the absorption of iodide, conversion of T4 to T3, and also participates in the modulation of the immune system (11, 101)

Cancer Chemother Pharmacol 67(5):11671178 Kanematsu S, Uehara N, Miki H, Yoshizawa K, Kawanaka A, Yuri T, Tsubura A (2010) Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells

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We conclude that it will be worth investigating the role of the abnormalities in the 1-carbon cycle and methylation cycle to explain pathoepigenetic modifications in subjects with DS