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In addition to physical instability, biological instability of nanoparticles is another concern, typically caused by the adsorption of biomolecules, including proteins, lipids, and enzymes, onto the particle surface

Therefore, we previously suggested that GSH efflux is necessary to some extent, but not sufficient, for the selective death induction of MRP1-expressing cells 18

Doulberis et al., 2020)

To disrupt SPI1 binding, site-directed mutagenesis was performed on the predicted binding sites using overlapping extension PCR

For Contrave, missed doses should be taken as soon as remembered unless it's close to the next scheduled dose, in which case the missed dose should be skipped to avoid doubling up