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PMID: 32 ItsumiMInoueSEliaAJMurakamiKSasakiMLindEFet al

Mol Cancer Ther 10(11):2094-103, 2011

Residues 102292) is the specific sequence that interacts with the responsive regions of P53 on DNA and modulates the transcription of genes associated with cell cycle regulation (such as CDKN1A/P21), apoptosis (BAX, PUMA), and antioxidant responses [46]

In addition to improving our understanding of this process, identifying genes and pathways involved will also help us to develop new therapeutic targets [21]