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J Neuropathol Exp Neurol (2019) 78(12):110011

Genetics also play a role

Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer

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The three enzymes depicted in Figure 2C MtdA, Fch, and Fhs constitute the central pathway for methyl transfer, which is required for the synthesis of purines and amino acids, and for the initiation of protein translation