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STAT5b in human subjects is critical for GH-induced IGF-I expression and growth promotion as demonstrated by the identification of mutations in the STAT5b gene of patients presenting with severe GH insensitivity in the presence of normal GHR (58)

RoghaniAKGarciaRIRoghaniAReddyAKhemkaSReddyRPet al

Based on the above findings, this novel lipase inhibitor is currently at the furthest stage in the clinical development of new drugs of this class (see Table 23)

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We then examined the binding interface between DET1 and Ube2e2