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Thus, similar to other toxin-induced demyelination models, lesion induction is probably not relevant to MS although some authors suggest that demyelination primarily induced by oligodendroglial damage linked to mitochondrial dysfunctions, as seen in MS pattern III and IV lesions, is mimicked by the cuprizone model (Torkildsen et al., 2008

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And kudos to Tobias for putting together great notes for us to Howard Forman: Absolutely. Harlan Krumholz:

We hypothesized that DECT collagen maps can visualize differences in the collagen content of thoracic discs, hence providing information on the degree of degenerative change