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Dihexa was administered to the APP/PS1 mice intraperitoneally from 6 to 9 months of age and 0.9% saline was administered to the wild type group once per day over a three month time period

CP attenuates the immune system by suppressing lymphocyte (T and B cell) growth, hence diminishing inflammation and the autoimmune mechanisms associated with rheumatic illnesses (Klein et al

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Moreno-Arrones OM, Serrano-Villar S, Perez-Brocal V, Saceda-Corralo D, Morales-Raya C, Rodrigues-Barata R, Moya A, Jaen-Olasolo P, Vano-Galvan S (2020) Analysis of the gut microbiota in alopecia areata: identification of bacterial biomarkers

This may involve increased iron uptake mediated by transferrin receptor 1 (TfR1) or reduced iron export facilitated by ferroportin (Fpn)