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One study demonstrated that curcumin combined with paclitaxel treatment was superior to paclitaxel-placebo combination therapy in terms of ORR and physical performance after 12 weeks of treatment, and there were also no major safety concerns or reduction in quality of life (Saghatelyan et al., 2020).EGCG synergistically enhances the efficacy of drugs such as 5 - Fluorouracil and cisplatin, and reduces cardiac, renal, and other organ EGCG may synergistically enhance the efficacy of drugs such as 5-fluorouracil and cisplatin and reduce the toxicity in the heart and kidney, but some drugs (e.g., bortezomib, sunitinib) may antagonize EGCG, but clinical evidence is limited, and further validation of their safety and efficacy is needed ( Despite their low bioavailability, oral polyphenols can modulate the intestinal flora through their antimicrobial properties, increasing the proportion of beneficial bacteria in the gut and reducing pathogenic bacteria (Scazzocchio et al., 2020)

To validate the reliability of the prediction model, permutation test ( n = 300) was calculated (Fig

When an adolescent discloses sensitive information or vulnerable concerns regarding sexual health, the physician must first establish rapport and validate the patient's proactive healthcare-seeking behavior before gathering further clinical details, making the most appropriate initial response 'I'm glad you came in today and told me about this.' Effective communication with adolescent patients requires building a foundation of trust before delving into sensitive sexual histories

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PMID 10591028