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The Neurofibromatoses: Introduction Epidemiology The modern age of neurofibromatosis began in 1981, with Riccardis detailed clinical descriptions of the features and natural history of von Recklinghausen disease and the subsequent description of central neurofibromatosis with bilateral acoustic neuroma. With the availability of gene-based diagnosis, several distinct clinical syndromes have been identified: (1) neurofibromatosis type 1 (NF-1), also known as von Recklinghausen disease

Membranes were blocked for 1 hr in blocking buffer (5% w/v solution of non-fat dry milk in TBS-T: 1X Tris-buffered saline (20 mM Tris, 150 mM NaCl) supplemented with 0.1% Tween-20 detergent)

doi: 10.1186/s10020-022-00481-w 37 LiJLeeYSChoiJSSungHYKimJKLimSSet al