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The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates

In addition to its antioxidant properties, glutathione helps regulate the function of immune cells, such as T-cells and macrophages, which are responsible for defending the body against infections and other harmful agents

10.1155/2015/201843 136 MillerK

In this study, the LDLR gene encoding for the LDL receptor was the top significant upregulated gene and more studies are needed to evaluate its role as a cell surface sensor or innate receptor in response to Al-CPI or whether it is implicated in the transcriptional changes of sterol metabolic genes