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For example, C16-carnitine (10 M) may impair mitochondrial function in rat ventricular myocytes by accelerating ROS production and increasing the probability of mitochondrial permeability transition pore (mPTP) opening, whereas low concentrations (1 and 5 M) of C16-carnitine lightly hyperpolarize the m but do not open the mPTP [293]

OReilly Media: Sebastopol, CA, 2015

In turn, this increment of BCAA derivatives may modulate insulin homeostasis in different ways, thereby creating a vicious cycle [25]

In very few cases, children can get seriously ill after exposure