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Interestingly, -catenin and its negative regulator APC were shown to be expressed in pericentral and periportal regions, respectively ( Lpr5 knockout mice resulted in the same disruption of hepatocyte heterogeneity as -catenin knockout mice (Yang et al., 2014), indicating that -catenin is regulated by Wnt signaling

Subsequently, this leads to less gene flow between distantly separated populations, thereby decreasing the genetic diversity of each area

Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM (2006) Targeting multidrug resistance in cancer