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In a recent study, Jbara and coworkers combined a structure-based design with total synthesis to generate abiotic TFs with refined structural and functional properties 57

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1 Introduction Mitochondria are organelles in almost all eukaryotic cells, performing essential functions such as ATP production, calcium signaling, lipid biogenesis, oxidative stress regulation, and apoptosis

For example, Epigallocatechin-3-gallate (EGCG) competitively inhibits DNMT1 and results in re-expression of gene silenced via DNMT1-mediated methylation [142,143,144]

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