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3 System Xc consists of a solute carrier family 7 members 11 (SLC7A11, or xCT) and solute carrier family 3 members 2

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As previously demonstrated, glpD / golD / uhpT mutants display a 12 log defect in both the spleen and liver, while ptsI mutants were 500-fold and 5000-fold attenuated in the spleens and livers of infected mice respectively (Fig 5A)

Research also provides more recent advances [2], as well as a background literature review of similar ideas going back to the 1930s [9]