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doi: 10.1016/j.bbadis.2016.11.005

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CagriSema's advantage is that semaglutide has a long clinical record, and amylin biology is conceptually complementary

An additional mode of communication from the gut to the brain includes the enteric nervous system (ENS) and sensory neurons expressing receptors to TNF-, IL-1 or IL-6 (243), and to 5-HT (244), which is abundantly produced at the gut level (245) (upwards black arrows in Figure 2 )