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Per ADA 2026 Standards of Care, treatment is individualized based on A1C targets, comorbidities (CVD, CKD, heart failure), hypoglycemia risk, weight effects, cost, and patient preference

Structurally, CAPS2 contains both a dynactin 1 interaction domain, suggesting that it may coordinate motor complex recruitment, and the Munc13-1 homologous domain, which is implicated in vesicle priming

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S., Cappuccino, A., & McAfee, P

However, a few studies have suggested that these actions of the trefoil peptides may also contribute to the movement of cancer cells, known as metastasis, in cell models