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A Novel Enantiospecific Synthesis of (S)-(-)-Methyl 6,8-Dihydroxyoctanoate, a Precursor of (R)-(+)--Lipoic Acid

In hepatocellular carcinoma, AMPK activation by ferroptosis inducers like erastin, sorafenib, and sulfasalazine inhibits branched chain amino acid transaminase 2 (BCAT2) transcription, modulating glutamate levels and preventing ferroptosis [69]

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Taking account of the mechanisms of ferroptosis, GSH-depleted methods have been extensively exploited for antitumor therapy based on GSH-enhanced GPX4 inactivity and LPO accumulation

Order-level analysis (Figure S6C) indicated Bacteroidales as a highly connected taxon, while phylum-level networks (Figure S6D) revealed Verrucomicrobiota as a central hub interacting with multiple phyla