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B12 is supplied as methylcobalamin, the stable form immediately used by the body

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Mechanism of Action of Vitamin B12 on Neurotransmitters Vitamin B12 plays several important roles in the nervous system and its deficiency can lead to neurological symptoms and may contribute to the development of neurodegenerative diseases

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These reports typically describe inflammatory acne lesions appearing within one to four weeks of initiating B12 therapy, with resolution following discontinuation