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doi: 10.1155/2016/2412958 146 CiminiAD'AngeloBDasSGentileRBenedettiESinghVet al

Data are presented as MeanSEM

Further studies have shown that genetic knockout of GPX4 induces cell death with characteristic features of ferroptosis, genetically confirming its central role in maintaining cellular lipid homeostasis and defending against oxidative damage (Dixon et al., 2012