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Numbness and tingling happens because B12 deficiency decreases your ability to maintain nervous system tissue, Loafman explains

Individuals with Digestive Disorders : Conditions like Crohns disease, celiac disease, or other gastrointestinal issues can interfere with B12 absorption

GLP-1 agonists commonly cause nausea, vomiting, and gastrointestinal distress, particularly during dose escalation

Concurrent Use with Other NNMT Inhibitors or Methylation Modulators Combining with supplements or drugs that also inhibit NNMT or alter methylation (e.g., SAMe , niacin , methylfolate , resveratrol ) could lead to: Excess NAD accumulation Methyl donor depletion Unpredictable metabolic effects Use caution and monitor methylation-related pathways if stacking 3